The Role of Magnesium in Human Body with Type 2 Diabetes

Type-2 Diabetes Mellitus (T2DM) stands a chronic sickness which needs continuing medical attention and ongoing patient self-disciplined education. There must be a support to avoid acute problems. It likewise diminishes the hazard of long-standing difficulties. T2DM precaution is multipart plus it involves that several subjects, beyond glycemic regulator, be spoke. A great indication subsists that chains a series of involvements to recover diabetic results. Diabetes is repeatedly interrelated by intracellular magnesium shortage plus extracellular. Insulin plus glucose are key magnesium metabolism regulators. Intracellular magnesium acting an significant title role in the parameter of insulin helpful action, glucose captivation as well as vascular tone.

Magnesium (Mg +2) is one of the seven macro-minerals essential. In more than 300 enzyme feedbacks in the body, it shows a significant title role. In the metabolism of glucose and carbohydrates, magnesium plays a vital role. A hardly any of readings have discovered the opposite new bond among magnesium (Mg+2) consumption and diabetes. Mg +2 deficiency is linked toward insulin opposition, metabolic syndrome, coronary heart disease and osteoporosis, and the hazard of evolving type-2 diabetes decreases by almost 15 %. In diabetic sufferings, especially those per poor glycaemic control, hypomagnesaemia occurs frequently.3 Magnesium builds a critical role as a cofactor in several hundred intracellular reactions.4 Mg+2 disorders are recurrently associated by way of chronic and metabolic illnesses, particularly T2DM, although the hypomagnesemia role in Type-2 Diabetes is not fully known. Glycemic control of T2DM and deficient Mg balance are closely linked.

Increased magnesium intake may improve insulin action and secretion, dyslipidaemia, and endothelial dysfunction, and vascular contractility plus diminution thrombotic tendency. Whether Mg supplementation has a clinically valuable effect on glycaemic control in diabetes, nevertheless, remains a difficulty of discussion. Hypomagnesemia is associated with low T2DM mechanisms and serum magnesium degradation arises significantly during the illness period. Emerging published evidence implies too that augmented Mg+2 consumption may decrease the threat of diabetes. Over the last millennium, the Mg+2 part has been progressively renowned in the anticipation and handling of hyperglycemic control.

One randomized trial described that the mean HbA1c was achieved 9.0±2.4% through Mg+2 supplementation and 9.0±1.3% by placebo in Type-II Diabetes sufferings that were presented with >9% HbA1c. The variance was noteworthy between equally groups in controlling HbA1c (p=0.04).7 But another trial showed that the mean HbA1c was achieved 7.90±1.68% with Mg+2 supplementation and 7.61±1.59% with placebo in T2DM patients. The variance was irrelevant among both groups in controlling HbA1c (p>0.05).

Rationale of this study is to compare the mean HbA1c level after treatment with oral magnesium supplementation versus placebo on glycemic regulator happening T2DM now the people who are magnesium deficient. Writings have conveyed that addition of magnesium supplementation along with standard management of T2DM can help in controlling glycemic near (HbA1c) and can prevent the sufferers from emerging other hazardous problems associated with uncontrolled HbA1c. But controversial results have been noticed in literature mentioned above. One study showed that magnesium supplementation is beneficial but other showed that there is no use of prescribing additional magnesium to standard treatment. So, to confirm the evidence we want to conduct this learning whether around is improvement or no improvement in glycemic regulator of type-2 diabetic patients who are magnesium deficient. This will help to improve our practice as well as will also help us to get local evidence, as there is no local study available which can help in implementing the use of additional Mg+2 to standard handling in Type-2 Diabetes patients.